DynamicSPECT of the Brain Using a LipophilicTechnetium - 99 m Complex

نویسندگان

  • Allan R. Andersen
  • Sissel Vorstrup
  • Niels A. Lassen
  • Olaf B. Paulson
  • Richard A. Holmes
چکیده

greatly facilitated by technetium-99m (99mTc)tracers, having comparable avid uptake and prolonged reten tion in the brain as the iodine-123-('231) labeled amines, isopropylamphetamine (IMP) and hydroxy benzyl-propanediamine (HIPDM). Such molecules would facilitate cerebral blood flow (CBF) tomography by conventional single photon emission computed to mography (SPECT). Technetium-99m is inexpensive, readily available, and well-suited for tomography be cause a high dose can be administered and because the energy of emission is optimal for the instruments. A lipophilic technetium chelate ofpropylene amine oxime (PnAO), passing the blood-brain barrier (BBB), has recently been described (1,2). The first-pass extraction efficiency of'PnAO in baboons was estimated to be 80% at normal blood flow (2). Propylene amine oxime is not retained in the brain but diffuses rapidly back from the brain tissue when the blood concentration drops. In

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تاریخ انتشار 2006